The Titans come in with a 2-4 record and one of the league's worst defenses ranking at 30th in terms of yardage allowed.
On the other sideline is the worst defense in the NFL through six weeks in the Buffalo Bills who are sitting at 3-3.
This game may not be one that everyone wants to watch but in terms of fantasy, whenever you get two bad defenses together that could mean a lot of points from unexpected places.
Tennessee Titans (2-4): Matt Hasselbeck has been steady through his three starts this season but with a very weak defense against him he could make some noise this weekend.
Chris Johnson has played well two of the last three weeks and has a great match-up. If you ever have confidence in starting him, this is the week.
Kenny Britt is nearly fully recovered from his knee and ankle injuries and is looking to have a breakout game this week.
Jared Cook has underperformed so far this season and is somewhat underused in the Titans' defense.
Good starts: Chris Johnson, Kenny Britt
Middle of the road: Kendall Wright, Nate Washington
Bad starts: Jared Cook
Buffalo Bills (3-3): Ryan Fitzpatrick is not the flashiest play but in a week that is full of good quarterbacks on bye he could be a good plug n' play with a terrific match-up.
C.J. Spiller and Fred Jackson are both safe plays as low-end RB2's or high-end flex plays.
Stevie Johnson will find the end zone again this week after a three-week drought.
Good starts: Ryan Fitzpatrick, C.J. Spiller, Fred Jackson, Stevie Johnson
Middle of the road: Scott Chandler
Bad starts: --